Prostate cancer patient from ERLEADA® (apalutamide) commercial with wife

LEARN ABOUT
ERLEADA^® AND
PROSTATE CANCER

LEARN ABOUT ERLEADA^®
AND PROSTATE CANCER

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How ERLEADA^® works

ERLEADA^® + ADT work together to lower androgens that can help fuel prostate cancer

When androgens attach to androgen receptors, they can help fuel prostate cancer cell growth

How androgens help fuel prostate cancer

Androgens are male hormones, primarily testosterone, that are needed for the prostate to function normally
However, when androgens attach to androgen receptors, they can help fuel prostate cancer cell growth

Androgen deprivation therapy lowers androgen levels

The goal of ADT is to lower androgen levels

Medical or surgical treatments that lower testosterone are also referred to as androgen deprivation therapy (ADT)
ADT includes treatment to suppress or block the production or action of male hormones called androgens

ERLEADA® blocks androgens from attaching to receptors

ERLEADA^® + ADT fight prostate cancer together

ERLEADA^® blocks androgens from attaching to receptors to help prevent cancer cells from growing

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Your Doctor

See clinical study results

Helpful Information and Resources

Get help paying for ERLEADA^®

Patient and doctor during office visit discussing ERLEADA® (apalutamide)

Doctor Discussion Guide

Contains questions to help start a conversation with your doctor.

Download

Boxing coach with prostate cancer from ERLEADA® (apalutamide) commercial ringside

ERLEADA^® Patient Brochure

Contains important information about mCSPC, nmCRPC, and ERLEADA^®.

Download

More helpful resources

Before taking ERLEADA^®, tell your healthcare provider about all your medical conditions, including if you:

Have a history of heart disease
Have high blood pressure
Have diabetes
Have abnormal amounts of fat or cholesterol in your blood (dyslipidemia)
Have a history of seizures, brain injury, stroke, or brain tumors
Are pregnant or plan to become pregnant. ERLEADA^® can cause harm to your unborn baby and loss of pregnancy (miscarriage)
Have a partner who is pregnant or may become pregnant
- Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 3 months after the last dose of ERLEADA^®
- Males should use a condom during sex with a pregnant female
Talk with your healthcare provider if you have questions about birth control.
Are breastfeeding or plan to breastfeed. It is not known if ERLEADA^® passes into breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ERLEADA^® can interact with many other medicines.

You should not start or stop any medicine before you talk with the healthcare provider that prescribed ERLEADA^®.

Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.

How should I take ERLEADA^®?

Take ERLEADA^® exactly as your healthcare provider tells you
Your healthcare provider may change your dose if needed
Do not stop taking your prescribed dose of ERLEADA^® without talking with your healthcare provider first
Take your prescribed dose of ERLEADA^® 1 time a day, at the same time each day
Take ERLEADA^® with or without food
Swallow ERLEADA^® tablets whole
If you miss a dose of ERLEADA^®, take your normal dose as soon as possible on the same day. Return to your normal schedule on the following day. You should not take extra tablets to make up the missed dose
You should start or continue a gonadotropin-releasing hormone (GnRH) analog therapy during your treatment with ERLEADA^® unless you have had a surgery to lower the amount of testosterone in your body (surgical castration)
If you take too much ERLEADA^®, call your healthcare provider or go to the nearest hospital emergency room

What are the possible side effects of ERLEADA^®?

ERLEADA^® may cause serious side effects including:

Heart Disease. Blockage of the arteries in the heart that can lead to death has happened in some people during treatment with ERLEADA^®. Your healthcare provider will monitor you for signs and symptoms of heart problems during your treatment with ERLEADA^®. Call your healthcare provider or go to the nearest emergency room right away if you get chest pain or discomfort at rest or with activity, or shortness of breath during your treatment with ERLEADA^®
Fractures and Falls. ERLEADA^® treatment can cause bones and muscles to weaken and may increase your risk for falls and fractures. Falls and fractures have happened in people during treatment with ERLEADA^®. Your healthcare provider will monitor your risks for falls and fractures during treatment with ERLEADA^®
Seizure. Treatment with ERLEADA^® may increase your risk of having a seizure. You should avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your healthcare provider right away if you have a loss of consciousness or seizure. Your healthcare provider will stop ERLEADA^® if you have a seizure during treatment

The most common side effects of ERLEADA^® include:

Feeling very tired
Joint pain
Rash. Tell your healthcare provider if you get a rash
Decreased appetite
Fall
Weight loss
Hypertension
Hot flash
Diarrhea
Fracture

ERLEADA^® may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility. Do not donate sperm during treatment with ERLEADA^® and for 3 months after the last dose of ERLEADA^®.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of ERLEADA^®.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see the full Prescribing Information for ERLEADA^®.

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What is ERLEADA®?

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How ERLEADA^® works